Mouse liver H3K27ac histone marks in male and female mouse liver for two mouse strains: C57BL/6J and CAST/EiJ.. Mouse liver H3K27ac histone marks in male and female mouse liver for two mouse strains: C57BL/6J and CAST/EiJ.

Sequencing files provided here are mouse liver ChIP-seq for the activating histone mark H3K27ac in two mouse strains: C57BL/6J and CAST/EiJ. This is part of a larger study published in PLoS Genetics (2021) "Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model" that includes RNA-seq and DNase-seq in mouse liver from the same two strains. This allows us to identify strain-shared ("core") and strain-unique sex-biased genes and enhancers. Overall design: H3K27ac ChIP-seq in male and female mouse liver

本数据集所附带的测序文件为两种小鼠品系（C57BL/6J与CAST/EiJ）小鼠肝脏中靶向激活型组蛋白修饰H3K27ac的染色质免疫共沉淀测序（ChIP-seq）数据。本数据隶属于2021年发表于《公共科学图书馆·遗传学》（PLoS Genetics）的一项大型研究，该研究论文题为"Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model"，其研究内容还涵盖上述两种品系小鼠肝脏的RNA测序（RNA-seq）与DNase I超敏感位点测序（DNase-seq）数据。依托该完整研究数据集，可鉴定品系共有（"core"）及品系特异性的性别偏向性基因与增强子。实验整体设计：针对雌雄小鼠肝脏的H3K27ac染色质免疫共沉淀测序（ChIP-seq）