Table_6_The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis.DOC

The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we created mice brain connectome and chemo-connectome databases based on mouse brain projection data of 295 non-overlapping brain areas and in situ hybridization (ISH) data of 50 representative neurotransmission-related genes from the Allen Brain Institute. Based on this connectome and chemo-connectome databases, functional connection patterns and detailed chemo-connectome for monoaminergic nuclei were analyzed and visualized. These databases will aid in the comprehensive research of the mouse connectome and chemo-connectome in the whole brain and serve as a convenient resource for systematic analysis of the brain connection and function.

大脑的各项功能依赖于脑内神经元复杂的连接网络与特定的分子特征。然而，当前小鼠脑连接组（connectome）与化学连接组（chemo-connectome）的数据库仍存在不足，这阻碍了脑环路与功能相关研究的开展。为此，我们基于艾伦脑科学研究所（Allen Brain Institute）提供的295个非重叠脑区的小鼠脑投射数据，以及50个代表性神经递质相关基因的原位杂交（in situ hybridization, ISH）数据，构建了小鼠脑连接组与化学连接组数据库。基于上述数据库，我们对单胺能核团的功能连接模式与精细化学连接组进行了分析与可视化。本数据库将助力全脑尺度小鼠连接组与化学连接组的系统性研究，并可为脑连接与功能的系统化分析提供便捷的研究资源。