Whole genome sequencing of 20 French and 20 Taiwanese wild mice. Whole genome sequencing of 20 French and 20 Taiwanese wild mice

The mouse is a premier model organism for mammalian biological re- search. They have been instrumental in studies illuminating processes of fundemental importance to genetics including the control of recom- bination and the process of speciation. However, most of these studies are based on laboratory mice, which are an artificial population with a complex relationship to wild mice. Studies of mammalian biology would benefit from understanding how history has shaped the genome of the present day mouse.In this work we analyze newly generated genotypes from whole genome sequencing of 20 French wild mice and 20 Taiwanese wild mice alongside additional wild and laboratory mice. We analyze demographic history, inbreeding, selection, and the effects of recombination.

小鼠是哺乳动物生物学研究中的旗舰模式生物（model organism）。其在阐明遗传学核心重要进程的研究中发挥了关键作用，涵盖重组调控与物种形成过程。然而，此类研究大多基于实验小鼠——后者是一类人工繁育种群，与野生小鼠存在复杂的演化关联。若能明晰历史如何塑造了现代小鼠的基因组，将对哺乳动物生物学研究产生极大推动。本研究针对20只法国野生小鼠、20只中国台湾野生小鼠，以及额外的野生与实验小鼠开展全基因组测序（whole genome sequencing），并分析由此生成的全新基因型（genotypes）；研究内容涵盖种群历史（demographic history）、近交（inbreeding）、选择作用以及重组（recombination）的影响效应。