MAPKAP kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

MK2 is essential for optimal macrophage differentiation into a pro-tumorigenic M2-like state. Overall design: RNA-seq were performed on M0 and M2 polarized macrophages isolated from bone marrow of MK2 wild type and knock out mice.

MK2 对于巨噬细胞向促肿瘤性M2样表型的最优分化至关重要。实验整体设计：对从MK2野生型与基因敲除小鼠骨髓中分离的M0极化巨噬细胞及M2极化巨噬细胞开展了RNA测序（RNA-seq）实验。