Data_Sheet_1_Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance.PDF

The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS.

七十余年来，负反馈系统（Negative Feedback System, NFS）一直被视作生理稳态调控的基本单元。然而，基于负反馈系统的建模方法存在一定局限性。自耦合系统（Self-Coupled System, SCS）作为一种将当前时刻的输出作为下一时刻输入的无间断系统，同样可用于刻画生理稳态。在基于自耦合系统的建模框架中，生理稳态的所有相关调控机制可被视为一个统一整体，进而可通过简洁的数学语言表述其动力学特性。通过数学推演，研究人员揭示了一类全新的疾病群组，并得到若干具有应用价值的推论，上述结果均已获得已发表文献的佐证支持。基于自耦合系统的生理稳态建模方法，理应成为基于负反馈系统的医学知识体系的必要补充。