Conditions and number of simultaneous CO_TD and CO_MF measurements.

Repartition of the different single simultaneous COTD and COMF measurements. A total of 98 CO measurements were performed in the 50 patients. Each COTD is the mean of 3 TD measurements (see Methods). Each COMF is the mean of 100 consecutive beat-by-beat values (see Methods). 26 patients (PAH n = 12, CTEPH n = 14) had a total of 48 measurements in conditions other than basal (PAH n = 25, CTEPH n = 23). #6 patients performed incremental exercise (PAH n = 4, CTEPH n = 2) with the workload being increased stepwise by 20 W every 3 min to a maximal workload of 60 W depending of patient functional tolerance for a total of 16 CO determined during steady exercise (PAH n = 9, CTEPH n = 7). NO: Nitric oxide vasoreactivity test; Fluid Challenge: CO determined after infusion of 500 ml of isotonic saline solution in five minutes; Bicycle rest: CO determined after 5 min of rest with feet positioned on the pedals with raised legs. Conditions and number of simultaneous COTD and COMF measurements.不同单次同步COTD与COMF测量的分布情况。本研究共纳入50例患者，完成总计98次心输出量（Cardiac Output, CO）测量。每例COTD为3次TD测量的平均值（详见方法部分）；每例COMF为100个连续逐搏数值的平均值（详见方法部分）。 26例患者（肺动脉高压（Pulmonary Arterial Hypertension, PAH）12例、慢性血栓栓塞性肺动脉高压（Chronic Thromboembolic Pulmonary Hypertension, CTEPH）14例）在非基础状态下完成总计48次测量（PAH组25次，CTEPH组23次）。另有6名患者（PAH组4例、CTEPH组2例）实施了递增负荷运动试验：运动负荷每3分钟以20 W的幅度逐级递增，最终根据患者的功能耐受情况达到最大60 W的负荷，稳态运动期间共完成16次心输出量测量（PAH组9次、CTEPH组7次）。 相关试验定义如下：一氧化氮（Nitric oxide）血管反应性试验；液体负荷试验（Fluid Challenge）：于5分钟内输注500 mL等渗生理盐水后测得的心输出量；自行车静息状态：患者双脚置于踏板、腿部抬起静息5分钟后测得的心输出量。 同步COTD与COMF测量的试验条件及例数。