Supplemental Figures and Tables: Clinicohistopathologic profile of patients who underwent Mohs micrographic surgery at the Dermatology Center of St. Luke’s Medical Center, Philippines from March 2003 - March 2018

ABSTRACT

BACKGROUND
Mohs Micrographic Surgery (MMS) has proven to be an effective technique in microscopically removing tumor foci while sparing normal tissue.

OBJECTIVE
To describe the clinical and histopathologic profile of patients who underwent MMS at the Dermatology Center of St. Luke’s Medical Center from March 2003 - March 2018.

METHODS
A retrospective review of MMS cases at the Dermatology Center from March 2003-March 2018.

RESULTS
Of 476 total MMS cases treated from 2003 to 2018, 404 cases with complete data were included. Mean age of the study population was 64.8 years old, with 94.9% in the >40 age group. Two hundred forty-two patients were Asians. The most common tumor was basal cell carcinoma (78%). More than half of cases (65.1%) were cleared of tumor after 2 stages. Based on the 5-year surveillance, there has been no recurrence of primary cases as of 2018. There were 2 (6.89%) recurrences amongst 29 recurrent tumors.

LIMITATIONS
This study is limited to MMS patients operated on at the Dermatology Center of St. Luke’s Medical Center.

CONCLUSION
The clinicohistopathologic profile of patients who underwent MMS is reflective of local, regional and international data. Post-operative data and surveillance prove that MMS is both a conservative and reliable approach to treatment of NMSCs.

摘要

## 研究背景
莫氏显微外科手术（Mohs Micrographic Surgery, MMS）已被证实为一种可在显微镜下精准切除肿瘤病灶、同时最大程度保留正常组织的有效术式。

## 研究目的
描述2003年3月至2018年3月期间，于圣卢克医疗中心皮肤科接受莫氏显微外科手术患者的临床与组织病理学特征。

## 研究方法
对2003年3月至2018年3月该皮肤科收治的莫氏显微外科手术病例开展回顾性分析。

## 研究结果
2003至2018年间共计完成476例莫氏显微外科手术，最终纳入数据完整的404例病例。研究人群的平均年龄为64.8岁，其中94.9%的患者年龄大于40岁；亚裔患者共242例。最常见的肿瘤类型为基底细胞癌（basal cell carcinoma），占总病例数的78%。超过半数（65.1%）的病例在2个手术阶段后实现肿瘤完全清除。经5年随访观察，截至2018年原发性病例未出现复发。在29例复发性肿瘤病例中，共有2例（6.89%）出现复发。

## 研究局限性
本研究仅纳入于圣卢克医疗中心皮肤科接受手术的莫氏显微外科手术患者，研究样本存在一定局限性。

## 研究结论
接受莫氏显微外科手术患者的临床组织病理学特征，与本地、区域及国际同类研究数据具有良好一致性。术后随访数据证实，莫氏显微外科手术是治疗非黑色素瘤皮肤癌（Non-Melanoma Skin Cancers, NMSCs）既保守又可靠的治疗方案。