Data_Sheet_1_Worsening of Preexisting Psychiatric Conditions During the COVID-19 Pandemic.docx

Objectives: To ascertain factors associated with worsening of psychiatric conditions during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: This study anonymously examined 2,734 psychiatric patients worldwide for worsening of their preexisting psychiatric conditions during the COVID-19 pandemic. An independent clinical investigation of 318 psychiatric patients from United States was used for verification.
Results: Valid responses mainly from 12 featured countries indicated self-reported worsening of psychiatric conditions in two-thirds of the patients assessed that was through their significantly higher scores on scales for general psychological disturbance, posttraumatic stress disorder, and depression. Female gender, feeling no control of the situation, reporting dissatisfaction with the response of the state during the COVID-19 pandemic, and reduced interaction with family and friends increased the worsening of preexisting psychiatric conditions, whereas optimism, ability to share concerns with family and friends, and using social media like usual were associated with less worsening. An independent clinical investigation from the United States confirmed worsening of psychiatric conditions during the COVID-19 pandemic based on identification of new symptoms that necessitated clinical interventions such as dose adjustment or starting new medications in more than half of the patients.
Conclusions: More than half of the patients are experiencing worsening of their psychiatric conditions during the COVID-19 pandemic.

研究目的：明确2019冠状病毒病（COVID-19）大流行期间精神疾病病情恶化的相关影响因素。
研究方法：本研究匿名纳入全球范围内2734名精神疾病患者，调查其在COVID-19大流行期间原有精神疾病的恶化情况；另选取美国地区318名精神疾病患者开展独立临床调研，以验证上述研究结果。
研究结果：来自12个核心参与国家的有效反馈显示，三分之二的受访患者自述原有精神疾病病情出现恶化，其在一般心理困扰量表、创伤后应激障碍量表及抑郁量表上的得分均显著升高。女性性别、对疫情局势缺乏掌控感、对国家疫情应对措施不满、与亲友互动减少，均会加重原有精神疾病的病情；而乐观心态、能够与亲友倾诉担忧、如常使用社交媒体，则与病情恶化程度较轻显著相关。美国地区的独立临床调研进一步验证了该结论：超过半数患者出现了新的临床症状，需要调整药物剂量或启动新的药物治疗等临床干预措施，证实了COVID-19大流行期间精神疾病病情的恶化态势。
研究结论：超过半数的精神疾病患者在COVID-19大流行期间出现了原有精神疾病的病情恶化。