NHLBI TOPMed - NHGRI CCDG: Early-onset Atrial Fibrillation in the CATHeterization GENetics (CATHGEN) Cohort

The CATHeterization GENetics (CATHGEN) biorepository collected biospecimens and clinical data on individuals age ≥18 undergoing cardiac catheterization for concern of ischemic heart disease at a single center (Duke University Medical Center) from 2000-2010; a total of N=9334 individuals were collected. Samples were matched at the individual level to clinical data collected at the time of catheterization and stored in the Duke Databank for Cardiovascular Diseases (DDCD). Clinical data included subject demographics, cardiometabolic risk factors, cardiac history including symptoms, age-of-onset of cardiovascular diseases, coronary anatomy and cardiac function at catheterization, laboratory data, and yearly follow-up for hospitalizations, vital status, medication use and lifestyle factors. AF cases were defined as individuals who had ever had AF based on any ECG available at Duke University or ICD-9 code for AF used for inpatient or outpatient billing.

心脏导管遗传学（CATHeterization GENetics, CATHGEN）生物样本库于2000年至2010年间，在单一研究中心杜克大学医学中心，为因疑似缺血性心脏病接受心脏导管检查的18岁及以上个体采集生物样本与临床数据，最终共纳入9334名受试者。所有样本均以个体为单位与导管检查时采集的临床数据进行匹配，并存储于杜克大学心血管疾病数据库（Duke Databank for Cardiovascular Diseases, DDCD）中。该数据库收录的临床数据涵盖受试者人口学特征、心脏代谢危险因素、含临床症状在内的心脏病史、心血管疾病发病年龄、导管检查时的冠状动脉解剖结构与心脏功能、实验室检测指标，以及针对住院情况、生存状态、药物使用与生活方式因素的年度随访数据。心房颤动（Atrial Fibrillation, AF）病例的定义为：经杜克大学留存的任意心电图（Electrocardiogram, ECG）结果确认，或使用用于住院/门诊计费的心房颤动国际疾病分类第9版（International Classification of Diseases 9th Revision, ICD-9）编码证实曾罹患心房颤动的受试者。