Isolation of six Streptomyces strains able to metabolize microbial glucans

The enzymatic degradation of microbial exopolysaccharides is less studied than plant cell wall polysaccharides, but detailed understanding could be relevant for the development of new therapeutics. Two types of pure microbial glucans were here used as the sole carbon source to isolate species able to metabolize them, and the genomes of six strains sequenced to gain insight into their carbohydrate-active enzyme repertoires to identify enzymes likely to be involved in the process.

相较于植物细胞壁多糖 (plant cell wall polysaccharides)，微生物胞外多糖 (microbial exopolysaccharides) 的酶促降解相关研究相对不足，但对该过程的深入认知或可助力新型治疗药物的开发。本研究以两种纯化的微生物葡聚糖作为唯一碳源，筛选能够代谢该类多糖的微生物物种，并对6株菌株的基因组进行测序，以解析其碳水化合物活性酶 (carbohydrate-active enzyme) 谱库，进而鉴定可能参与该降解过程的酶类。