Hypertension and maternal urinary tract infection and the metabolic conditions of preterm infants

ABSTRACT Objective: The present study evaluated the anthropometric and metabolic profiles of preterm infants (PT) born from mothers with urinary tract infections (UTI) and mothers with hypertensive disorders (HD). Method: This was a longitudinal prospective study conducted between May 2015 and August 2016. First, 59 mothers with premature birth were included; after excluding 29 mothers, two subgroups were created: UTI-mothers (n=12) and HD-mothers (n=18). The anthropometric and metabolic variables of mothers and their respective PT were analyzed at birth and at 6 months of corrected age (CA). Results: Plasma triglyceride levels were higher among HD-mothers and their respective PT in comparison with UTI-mothers and their PT at 6 m of CA. Conclusion: Plasma triglyceride level is an important metabolic biomarker in HD-mothers resulting in higher triglyceride levels among PT at the CA of 6 m, suggesting an early programming effect of maternal hypertension.摘要 研究目的：本研究旨在评估尿路感染（urinary tract infections, UTI）产妇及妊娠高血压疾病（hypertensive disorders, HD）产妇所分娩早产儿（preterm infants, PT）的人体测量学特征与代谢谱。 研究方法：本研究为一项于2015年5月至2016年8月开展的纵向前瞻性研究。最初纳入59名早产产妇，经剔除29名后，分为两个亚组：UTI产妇组（n=12）与HD产妇组（n=18）。分别于分娩时及矫正胎龄（corrected age, CA）6个月时，对产妇及其对应早产儿的人体测量学指标与代谢变量进行分析。 研究结果：在矫正胎龄6个月时，HD产妇组及其对应早产儿的血浆甘油三酯水平均高于UTI产妇组及其对应早产儿。 研究结论：血浆甘油三酯水平是HD产妇的重要代谢生物标志物，其可导致其所分娩早产儿在矫正胎龄6个月时出现更高的甘油三酯水平，提示母体高血压存在早期程序化效应。