Data, statistical analysis and graphics.

We developed a model of MMAE-induced CIPN and CICI and used behavior and sensory tests to analyze these conditions. We also evaluated calcium signaling in neuropathic tissues and tumor progression upon treatments with lithium and MMAE. <b>Results:</b> We found that MMAE administration leads to loss of peripheral sensitivity and cognitive impairment and lithium prevents both central and peripheral neuropathies induced by chemotherapy, without affecting the antitumor activity of MMAE.

我们构建了单甲基澳瑞他汀E（MMAE）诱导的化疗诱导性周围神经病（Chemotherapy-induced peripheral neuropathy, CIPN）与化疗诱导性认知障碍（Chemotherapy-induced cognitive impairment, CICI）模型，并通过行为学检测与感觉功能实验对该类病症进行分析。此外，我们还评估了神经病变组织中的钙信号通路，以及经锂剂与MMAE治疗后的肿瘤进展情况。<b>结果：</b>我们发现，MMAE给药会导致外周感觉丧失与认知功能受损，而锂剂可有效缓解化疗诱导的中枢与外周神经病变，且不会影响MMAE的抗肿瘤活性。