Mn-promoted Aerobic Oxidative C–C Bond Cleavage of Aldehydes with Dioxygen Activation: A Simple Synthetic Approach to Formamides

A novel Mn-promoted aerobic oxidative C–C bond cleavage of aldehydes with dioxygen activation has been developed. The usage of molecular oxygen (1 atm) as oxidant, reactant, and an initiator to trigger this transformation makes this transformation very green and practical. A plausible radical process is proposed on the basis of mechanistic studies. Furthermore, this method provides a practical, neutral, and mild synthetic approach to formamides, which are important units in biologically active molecules.

本研究开发了一种新型锰（Mn）促进的、基于氧气活化的醛类需氧氧化C-C键断裂反应。采用1大气压的分子氧作为氧化剂、反应物与引发剂来触发该转化过程，使得该方法兼具绿色性与实用性。基于机理研究，本文提出了一种合理的自由基反应历程。此外，该方法为甲酰胺类化合物提供了一种实用、中性且温和的合成路径，而甲酰胺是生物活性分子中的重要结构单元。