ATAC-seq in WT, p53-ko, Ezh2-ko primary macrophages

Assess chromatin accessibility in WT, p53-ko, Ezh2-ko primary macrophages using ATAC-seq. Overall design: ATAC-seq was performed on 50000 cells in WT, p53-ko, Ezh2-ko primary macrophages

本数据集采用ATAC-seq（转座酶可及性染色质测序，Assay for Transposase-Accessible Chromatin using sequencing）技术，对野生型（Wild Type，WT）、p53基因敲除（p53 knockout，p53-ko）及Ezh2基因敲除（Ezh2 knockout，Ezh2-ko）原代巨噬细胞的染色质可及性进行检测。实验整体设计：针对上述三类原代巨噬细胞的5万个细胞开展ATAC-seq实验。