TCGA Chemotherapy Response Dataset

Dataset on chemotherapeutic drug responses in TCGA cancer patients, cross-referenced for a hit in TCIA.at database, consisting of clinical (TCGA), cancer tissue gene-expression (TCGA) and tumor-immunome (TCIA) features. The dataset consists of 5 common chemotherapy agents, 3 CRC agents (FOLFOX, 5FU, Oxaliplatin) and 2 Lung agents (Carboplatin, Cisplatin). FOLFOX as a combinational therapy or regimen, was compiled from timings of monotherapies given to patients and as such is a novel dataset derived from TCGA data. FOLFOX dataset is primarily firstline treatment, while other drugs are not to be interpreted as firstline treatments. Drug datasets are individually available in own CSV files. <strong>Citation</strong><br> Dalibor Hrg, Balthasar Huber, Lukas A. Huber. (2020). TCGA Chemotherapy Response Dataset. Zenodo. http://doi.org/10.5281/zenodo.3719291 The results here are in whole or part based upon data generated by the TCGA Research Network: https://www.cancer.gov/tcga. <strong>License </strong><br> CC BY-SA 4.0 International https://creativecommons.org/licenses/by-sa/4.0. Authors take no liability for any use of this data. <strong>Contributions</strong><br> D. Hrg and B. Huber acknowledge major and equal work effort: data understanding, data science and dataset preparation (monotherapies and FOLFOX); L. A. Huber: help with dictionary of drug names and curration/cleaning of FOLFOX entries, clinical validation. <strong>Contact &amp; Maintenance</strong><br> [e-mail]<br> [e-mail]本数据集为TCGA癌症患者化疗药物响应数据集，与TCGA.at数据库中的匹配结果进行了交叉验证，包含临床（TCGA）、癌组织基因表达（TCGA）以及肿瘤免疫组（TCIA，The Cancer Imaging Archive）特征。 本数据集涵盖5种常用化疗药物，其中3种结直肠癌（Colorectal Cancer，CRC）用药（FOLFOX、5FU、奥沙利铂（Oxaliplatin）），2种肺癌用药（卡铂（Carboplatin）、顺铂（Cisplatin））。FOLFOX作为联合治疗方案，是基于患者单药给药时序整理得到的新型TCGA衍生数据集。 FOLFOX数据集主要对应一线治疗方案，其余药物则不应被认定为一线用药。各药物数据集均以独立CSV文件形式提供。 **引用信息** 达利博尔·赫格（Dalibor Hrg）、巴尔塔萨尔·胡伯（Balthasar Huber）、卢卡斯·A·胡伯（Lukas A. Huber）. (2020). TCGA化疗响应数据集. Zenodo. http://doi.org/10.5281/zenodo.3719291 本研究结果全部或部分基于TCGA研究网络生成的数据：https://www.cancer.gov/tcga. **许可证** CC BY-SA 4.0 国际授权协议 https://creativecommons.org/licenses/by-sa/4.0. 作者不对本数据的任何使用承担法律责任。 **贡献声明** D. 赫格与B. 胡伯贡献均等，共同负责数据梳理、数据科学分析与数据集制备（含单药方案与FOLFOX联合方案）；L. A. 胡伯：协助编制药物名称词典、完成FOLFOX条目的审核与清洗，以及临床验证工作。 **联系方式与维护** [e-mail] [e-mail]