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Structure of metacyclic VSG (mVSG) 531 from Trypanosoma brucei

NIAID Data Ecosystem2026-05-02 收录

锥虫VSG结构解析

寄生虫抗原变异

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https://www.rcsb.org/structure/8B3B 数据链接链接失效反馈

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Structure of metacyclic VSG (mVSG) 531 from Trypanosoma brucei

布氏锥虫（Trypanosoma brucei）中编号为531的循环型变异表面糖蛋白（metacyclic Variant Surface Glycoprotein，缩写mVSG）的结构

应用场景：

创建时间：

2024-10-23

寄生虫抗原变异

进化实验

Antigen switch frequency and developmental capacity are independently selected traits RNA samples were taken in triplicate at two points - at the beginning and end of in vitro selection for loss of pl

NIAID Data Ecosystem90

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei

寄生虫抗原变异

表观遗传调控

The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contai

NIAID Data Ecosystem30

Sequencing of the expressed VSGs in T. brucei cells where monoallelic VSG expression has been disrupted.. VSG seq T. brucei

寄生虫抗原变异

单等位基因表达

In the mammalian host, Trypanosoma brucei is coated in a single variant surface glycoprotein (VSG) species and stochastic switching allows the parasite to escape detection by the host immune system. T

NIAID Data Ecosystem20

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

寄生虫抗原变异

DNA损伤修复机制

Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by ‘70 bp’-repeats and tel

NIAID Data Ecosystem40

Babesia bovis wild-type and Bbrad51-knockout ves1a transcript Raw sequence reads. Babesia bovis strain:Mexico | isolate:CE11

寄生虫抗原变异

基因功能缺失分析

Goal was to determine the effects that loss of the BbRad51 protein would have on the ability of Babesia bovis to carry out rapid antigenic variation by segmental gene conversion.

NIAID Data Ecosystem20

Structure of metacyclic VSG (mVSG) 531 from Trypanosoma brucei

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