The Biological Residue of Low Early-Life Social Class

Research shows that children who are reared in households with low socioeconomic status are more vulnerable to heart disease, respiratory infection, and some cancers when they reach adulthood. This study conducted transcriptional profiling of PBMC in healthy adults who were low vs. high in early-life SES to explore the long-lasting genomic effects of early experience. Keywords: life stress, gene expression, inflammation, socioeconomic status Samples from 30 adults with low early-life SES and 30 adults with high early-life SES

研究表明，在低社会经济地位（socioeconomic status, SES）家庭中成长的儿童，成年后罹患心脏病、呼吸道感染及部分癌症的风险显著升高。本研究针对早期社会经济地位（SES）高低有别的健康成年人，对外周血单个核细胞（Peripheral Blood Mononuclear Cell, PBMC）开展转录谱分析，旨在探究早期生活经历所带来的长期基因组效应。关键词：生活压力、基因表达、炎症、社会经济地位。本研究样本涵盖30名早期社会经济地位较低的成年人与30名早期社会经济地位较高的成年人。