The Effect of Topical Antibiotic or Antibiotic-Corticosteroid Treatment on the Ocular Surface Microbiota of Healthy Horses

This study aimed to describe the bacterial ocular surface microbiota in healthy horses and evaluate the effect of topical antibiotics or antibiotic-corticosteroid medication on the ocular surface microbiota. This was a prospective, randomized, longitudinal, blinded study in which one eye of 12 horses was treated 3 times daily for 7 days with neomycin, polymyxin B and bacitracin ophthalmic ointment (n = 6) or neomycin, polymyxin B and dexamethasone (n = 6). The contralateral eyes operated as untreated controls.本研究旨在描述健康受试马的眼部表面细菌菌群（bacterial ocular surface microbiota），并评估局部应用抗生素或抗生素-糖皮质激素药物对眼部表面菌群的影响。本研究为一项前瞻性、随机、纵向、盲法研究，共纳入12匹受试马，每匹受试马的单侧眼部每日给药3次、连续给药7天，其中6匹使用新霉素、多粘菌素B与杆菌肽眼用软膏（ophthalmic ointment），另外6匹使用新霉素、多粘菌素B与地塞米松；所有受试马的对侧眼均作为未处理对照。