Transcription profiling of human breast cancer metatases from different organs (U133A)

Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Experiment Overall Design: 58 breast cancer metastases from different organs were profiled and compared by the expression level of over 400 cytokines. 36 samples were incuded in this series. 22 others as well as 7 of these 36 were profiled on U133plus2 platforms and included in series GSE14017.

对不同器官来源的乳腺癌转移瘤进行比对分析后发现，其微环境因细胞因子（cytokine）组成差异而呈现显著区别。此类微环境差异或许是决定癌细胞在成功定植前如何适应并存活的核心影响因素。实验总体设计：本研究针对58例不同器官来源的乳腺癌转移瘤开展表达谱分析，并以超过400种细胞因子的表达水平作为比对依据。本系列共纳入36例样本，其中22例样本以及该36例中的7例，曾在U133plus2基因芯片平台完成表达谱检测，并被纳入数据集GSE14017。