CA-4P

CA-4P investigates the impact of Lactobacillus paracasei treatment on the gut microbiota in Clostridioides difficile infection. Fecal samples from mice post-infection were processed using Invitrogen with sequencing on the Ion Torrent NGS System. Analysis via Ion Reporter SW (16S) revealed shifts in microbial taxa dynamics over days 1, 3, and 6, shedding light on the potential of probiotics in modulating gut microbiota during C. difficile infection.The identification of the sample CA-4P:<br>C: Denotes the strain ST-2 of Clostridioides difficile.<br>A: Represents timepoint 1, indicating sampling before C. difficile infection.<br>3: Refers to the specific mouse number under investigation.<br>P: Indicates the treatment administered, which in this case is Lactobacillus paracasei.

本数据集CA-4P旨在探究副干酪乳杆菌（Lactobacillus paracasei）干预对艰难梭菌（Clostridioides difficile）感染小鼠肠道菌群的影响。实验收集了感染后小鼠的粪便样本，采用英维康（Invitrogen）试剂盒进行前处理，并通过Ion Torrent下一代测序（NGS）系统完成测序。借助Ion Reporter SW（16S分析模块）开展分析后，研究人员观察到在感染后第1、3、6天，微生物类群的动态丰度发生显著变化，该结果为阐明益生菌在艰难梭菌感染期间调控肠道菌群的潜在作用提供了重要依据。样本CA-4P的含义说明如下：<br>C：代表艰难梭菌菌株ST-2；<br>A：对应采样时间点1，即艰难梭菌感染前的采样节点；<br>3：指代本次研究的特定小鼠编号；<br>P：表示所施加的干预措施，本研究中为副干酪乳杆菌处理。