Baseline characteristics of 12-week & 18th-week follow-up of cognitive motor dual-task training in type 2 diabetes mellitus subjects.

A randomized controlled, and parallel three-arm trial with patient blinding. A total of 93 patients with T2DM (type 2 diabetes mellitus) aged 40-65 of either gender with HbA1c > 6.5 mmol/dL and more than 5 years of education. The eligible subjects underwent for baseline assessment of Gender, Age, duration of disease, education levels, HbA1c levels, BMI and Mini-Mental State Examination score. Then the subjects were allocated to each group through a random lottery method. After allocation, the subjects in experimental group A received CMDBT (cognitive motor dual-task blindfold training), experimental group B received CMDT (cognitive motor dual-task training), and the control group received conventional therapy of aerobic and resistance training for 3 sessions/week for 12 consecutive weeks. Participants were evaluated at 3 different times (baseline, completion at 12 weeks, and follow-up at 18 weeks) for every outcome. Primary outcome measures are the Montreal Cognitive Assessment, the Trail Making Test, and the WHO QoL BREF.一项采用患者设盲的随机对照平行三臂试验。共纳入93例年龄40~65岁、男女兼具的2型糖尿病（type 2 diabetes mellitus, T2DM）患者，其糖化血红蛋白（HbA1c）水平＞6.5 mmol/dL，且受教育年限超过5年。符合入组标准的受试者接受基线评估，评估指标涵盖性别、年龄、病程、受教育水平、糖化血红蛋白水平、体质量指数（Body Mass Index, BMI）以及简易精神状态检查（Mini-Mental State Examination）评分。随后采用随机抽签法将受试者分配至各组。分组完成后，实验组A接受认知运动双任务蒙眼训练（cognitive motor dual-task blindfold training, CMDBT），实验组B接受认知运动双任务训练（cognitive motor dual-task training, CMDT），对照组则接受常规有氧联合抗阻训练疗法，干预频率为每周3次，连续开展12周。研究分别于3个时间点（基线、12周干预结束时、18周随访时）对所有结局指标进行评估。主要结局指标包括蒙特利尔认知评估量表（Montreal Cognitive Assessment）、连线测验（Trail Making Test）以及世界卫生组织生存质量测定量表简版（WHO QoL BREF）。