Table1_Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study.pdf

BackgroundCardiac troponins and NT-proBNP are biomarkers of cardiac injury that are used clinically in the diagnosis of myocardial infarction and heart failure. It is not known whether the amount, types and patterns of physical activity (PA) and sedentary behaviour are associated with levels of cardiac biomarkers.
MethodsIn the population-based Maastricht Study (n = 2,370, 51.3% male, 28.3% T2D) we determined cardiac biomarkers hs-cTnI, hs-cTnT, and NT-proBNP. PA and sedentary time were measured by activPAL and divided into quartiles [quartile 1 (Q1) served as reference]. The weekly pattern of moderate-to-vigorous PA (insufficiently active; regularly actives; weekend warriors) and coefficient of variation (CV) was calculated. Linear regression analyses were conducted with adjustment for demographic, lifestyle, and cardiovascular risk factors.
ResultsThere was no consistent pattern between physical activity (different intensities: total, light, moderate-to-vigorous and vigorous) and sedentary time on the one hand and hs-cTnI and hs-cTnT on the other. Those with the highest levels of vigorous intensity PA had significantly lower levels of NT-proBNP. With regard to PA patterns, weekend warriors and regularly actives had lower levels of NT-proBNP but not with hs-cTnI and hs-cTnT (reference:insufficiently actives). A higher weekly moderate-to-vigorous PA CV (indicating more irregular activity) was associated with lower levels of hs-cTnI and higher levels of NT-proBNP, but not with hs-cTnT.
ConclusionsIn general, there was no consistent association between PA and sedentary time and cardiac troponins. In contrast, vigorous and possibly moderate-to-vigorous intensity PA, especially if done regularly, were associated with lower levels of NT-proBNP.

研究背景
心肌肌钙蛋白（Cardiac troponins）与N末端B型利钠肽原（NT-proBNP）是心脏损伤生物标志物，临床常用于心肌梗死与心力衰竭的诊断。目前尚不明确体力活动（Physical Activity，以下简称PA）与久坐行为的总量、类型及模式是否与心脏生物标志物水平存在关联。

研究方法
本研究纳入基于人群的马斯特里赫特研究（n=2370，男性占比51.3%，2型糖尿病（Type 2 Diabetes，以下简称T2D）患者占比28.3%）的研究对象，检测其心脏生物标志物高敏心肌肌钙蛋白I（high-sensitivity cardiac troponin I, hs-cTnI）、高敏心肌肌钙蛋白T（high-sensitivity cardiac troponin T, hs-cTnT）及NT-proBNP水平。采用activPAL活动记录仪测量体力活动与久坐时长，并将其按四分位分组（以第一四分位组Q1作为参照）。计算周度中到剧烈体力活动模式（运动不足人群、规律运动人群、周末勇士型人群）及变异系数（Coefficient of Variation，以下简称CV）。采用线性回归分析，并对人口学特征、生活方式及心血管危险因素进行校正。

研究结果
不同强度体力活动（总体力活动、轻强度、中到剧烈强度及剧烈强度）与久坐时长，分别与hs-cTnI、hs-cTnT之间未呈现一致的关联模式。其中，剧烈强度体力活动水平最高的人群，其NT-proBNP水平显著更低。就体力活动模式而言，周末勇士型与规律运动人群的NT-proBNP水平显著低于参照组（运动不足人群），但hs-cTnI与hs-cTnT水平未呈现此类差异。周度中到剧烈体力活动CV越高（提示运动越不规律），与hs-cTnI水平降低、NT-proBNP水平升高相关，但与hs-cTnT水平无显著关联。

研究结论
总体而言，体力活动与久坐时长和心肌肌钙蛋白之间未呈现一致的关联。与之相反，剧烈体力活动，或潜在的中到剧烈强度体力活动，尤其是规律进行时，与NT-proBNP水平降低相关。