Additional file 1 of DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

Additional file 1: Supplementary Table 1. Clinical features of the cohort. Supplementary Table 2. PostQC sample information. Supplementary Table 3. PMD genome coverage per sample. Supplementary Table 4. PMDs common to ovarian cancer (ovcaPMDs). Supplementary Table 5. Enriched pathways for genes in PMDs. Supplementary Table 6. DMRs from Primary vs Recurrent. Negative values indicate regions hypermethylated in recurrent samples. Supplementary Table 7. DEGs from Primary vs Recurrent. Supplementary Table 8. Genes near Primary vs Recurrent DMRs intersecting DEGs. Supplementary Table 9. DMRs from BC vs NC. Supplementary Table 10. DMRs from BC vs NC (hg19) that overlap 450k probes within 300bp. Supplementary Table 11. DEGs from BC vs NC. Supplementary Table 12. Genes near BC vs NC DMRs intersecting DEGs

附加文件1：补充表1. 研究队列的临床特征。补充表2. 质控后样本信息。补充表3. 各样本的部分甲基化结构域（PMD，Partially Methylated Domain）基因组覆盖度。补充表4. 卵巢癌共有的部分甲基化结构域（ovcaPMDs）。补充表5. 部分甲基化结构域内基因的富集通路。补充表6. 原发灶与复发灶的差异甲基化区域（DMRs，Differentially Methylated Regions）：负值提示复发样本中对应区域呈高甲基化状态。补充表7. 原发灶与复发灶的差异表达基因（DEGs，Differentially Expressed Genes）。补充表8. 原发灶与复发灶差异甲基化区域附近、与差异表达基因存在交集的基因。补充表9. 乳腺癌（BC，Breast Cancer）与正常对照（NC，Normal Control）的差异甲基化区域（DMRs）。补充表10. 基于hg19基因组版本的乳腺癌（BC）与正常对照（NC）的差异甲基化区域（DMRs），此类区域与300bp范围内的450k探针存在重叠。补充表11. 乳腺癌（BC）与正常对照（NC）的差异表达基因（DEGs）。补充表12. 乳腺癌（BC）与正常对照（NC）的差异甲基化区域（DMRs）附近、与差异表达基因（DEGs）存在交集的基因