Effects of MMPIP, LY341495, and MK801, mPFC infusions on the number of correct responses and response latencies in a VITI version of the 5CSRTT.

The effect of intracerebral infusions into the prelimbic and infralimbic cortices of MMPIP (0.0–1.0 µg/µL), LY341495 (0.0–10.0 µg/µL), and MK801 (0.0–10.0 µg/µL) on correct responses and response latencies in a VITI version of the 5CSRTT. Results are shown for the total population, mean ± SEM, prelimbic MMPIP n = 10, LY341495 and MK801 n = 9, infralimbic n = 6 animals per group, within-subject, *p<0.05 versus vehicle. 5CSRTT 5-choice serial reaction time task, Csec centiseconds, VITI variable inter-trial interval. Effects of MMPIP, LY341495, and MK801, mPFC infusions on the number of correct responses and response latencies in a VITI version of the 5CSRTT.向 prelimbic皮层（prelimbic cortex）与infralimbic皮层（infralimbic cortex）脑内分别输注MMPIP（0.0~1.0 µg/µL）、LY341495（0.0~10.0 µg/µL）及MK801（0.0~10.0 µg/µL），对5选择连续反应时任务（5-choice serial reaction time task，简称5CSRTT）的试间间隔可变（variable inter-trial interval，简称VITI）版本中正确反应数与反应潜伏期的影响。实验结果以总群体的均值±标准误呈现：prelimbic皮层给药组中，MMPIP组动物数n=10，LY341495与MK801组均为n=9；infralimbic皮层给药组每组动物数n=6，实验采用被试内设计，*p<0.05，与溶剂对照组相比。 5CSRTT即5选择连续反应时任务，Csec为厘秒，VITI即试间间隔可变。 经内侧前额叶皮层（medial prefrontal cortex，mPFC）输注MMPIP、LY341495及MK801后，对5CSRTT的VITI版本中正确反应数与反应潜伏期的影响。