Potentially functional APA alleles are positively correlated with risk alleles from GWAS SNPs.

Two predicates were tested in a binomial setting: for positive trend correlation between APA and risk alleles, and for the strength of the correlation. For the 60 APA-SNPs paired to GWAS-SNPs, the proportions of and were respectively and . Among the 9 SNPs identified in the previous sections as functional candidate, respectively 8 and 5 succeeded the Bernoulli trial. Both null hypotheses were rejected.在二项分布检验框架下，共对两项统计假设开展检验：其一为APA与风险等位基因间的正向趋势相关性，其二为该相关性的强度。针对与GWAS-SNPs配对的60个APA-SNPs，两类指标的占比分别为与。在既往研究章节中被鉴定为功能候选的9个单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）中，分别有8个和5个通过了伯努利试验。两项原假设均被拒绝。