Prevalence of intrinsic disorder in the studied DISC1 pathway proteins, as measured by DisProt analysis.

(A) Disorder content of the individual proteins of the DISC1 pathway (i.e. percentage of disordered residues/ total number of amino acids). (B) Disorder content of the DISC1 pathway proteins compared to human proteome (i.e. 20320 SwissProt proteins), a set of brain proteins (7160 sequences from GeneAtlas) and a set of schizophrenia candidate proteins (670 sequences from the Schizophrenia Gene Resource database). Overall, the DISC1 pathway proteins exhibit a higher abundance of intrinsically disordered residues, compared to the human proteome.

(A) DISC1通路（DISC1 pathway）各单个蛋白质的无序化程度，即无序残基数量占氨基酸总残基数的百分比。(B) DISC1通路蛋白质的无序化程度与人类蛋白质组（即20320条Swiss-Prot来源蛋白质）、一组脑蛋白质（来自GeneAtlas数据库的7160条序列）以及一组精神分裂症候选蛋白质（来自精神分裂症基因资源数据库的670条序列）的对比结果。总体而言，与人类蛋白质组相比，DISC1通路蛋白质的固有无序残基（intrinsically disordered residues）丰度更高。