GNPS Metabolomics Workbench ST001257 - GNPS Nutrimetabolomics and DASH diet

b'Although health benefits of the Dietary Approaches to Stop Hypertension (DASH) diet are established, it is not understood which food compounds result in these benefits. We used a step-wise approach to identify unique compounds from individual foods of a DASH-style diet, determined if these Food-Specific Compounds (FSC) are detectable in urine, and then examined relationships between urinary FSC and blood pressure (BP). Nineteen subjects were randomized into 6-week controlled DASH-style diet interventions. Untargeted, LC/MS-based metabolomics was performed on 24-hour urine samples collected before and after each intervention and on 12 representative DASH-style foods.'

尽管终止高血压膳食疗法（Dietary Approaches to Stop Hypertension, DASH）的健康益处已得到证实，但目前尚不明确究竟是何种食物成分促成了这些益处。本研究采用分步策略，从终止高血压膳食疗法风格饮食的各类单一食物中鉴定独特成分，确认这些食物特异性成分（Food-Specific Compounds, FSC）能否在尿液中被检测到，随后探究尿液中食物特异性成分与血压（Blood Pressure, BP）之间的关联。本研究将19名受试者随机分配至6周的受控终止高血压膳食疗法风格饮食干预组。针对每次干预前后采集的24小时尿液样本，以及12种具有代表性的终止高血压膳食疗法风格食物，开展了非靶向液相色谱-质谱联用法（Liquid Chromatography-Mass Spectrometry, LC/MS）代谢组学分析。