RNA-Seq of primary CKD osteoblasts

Primary osteoblasts from patients with end-stage kidney disease have defective maturation and mineralization characteristics in vivo and in vitro. This study was designed to evaluate signaling pathways associated with this abnormal maturation phenotype. Cross-sectional RNA-Seq analysis of primary osteoblasts from 9 pediatric end-stage kidney disease patients and 3 healthy controls grown to confluence

终末期肾病（end-stage kidney disease）患者来源的原代成骨细胞（primary osteoblasts）在体内及体外环境中均表现出成熟与矿化功能缺陷的表型特征。本研究旨在解析与该异常成熟表型相关的信号通路，并针对9名儿科终末期肾病患者与3名健康对照者的汇合状态原代成骨细胞开展了横断面RNA-Seq分析。