Skin and stool microbiota in children with food allergy

Food allergy (FA) affects up to 10 % of children, especially children with atopic dermatitis (AD). During infancy, skin and gut microbiome may determine both the course of FA and the tolerance to food allergy, like colonization with Staphylococcus aureus have a higher risk of persisting egg and peanut allergy. This colonialization might play a role in the dysfunction of the skin barrier and therefore play a role in allergic sensitization. We investigated the development of gut and skin microbiome in children after their first allergic reaction over time. Understanding of the impact of the microbiome on the clinical course of FA and AD may allow for the development of new models of allergy treatment and prevention.

食物过敏（Food Allergy, FA）可影响多达10%的儿童，其中患有特应性皮炎（Atopic Dermatitis, AD）的儿童受影响更为显著。在婴儿期，皮肤与肠道微生物组（microbiome）可同时调控食物过敏的病程与过敏耐受状态；例如，若儿童皮肤定植金黄色葡萄球菌（Staphylococcus aureus），则其持续罹患鸡蛋及花生过敏的风险显著升高。此种定植过程可能参与皮肤屏障功能异常，进而在过敏致敏过程中发挥关键作用。本研究针对首次发生过敏反应的儿童，长期追踪其肠道与皮肤微生物组随时间的动态演变。明晰微生物组对食物过敏及特应性皮炎临床病程的影响，或将助力开发新型过敏治疗与预防策略。