PhI(OCOCF3)2‑Mediated C–C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3‑Arylquinolin-2-ones

The reaction of the readily available N-methyl-N-phenylcinnamamides with phenyliodine bis(trifluoroacetate) (PIFA) in the presence of Lewis acids provides a general and efficient assembly of a variety of 3-arylquinolin-2-one compounds. This novel approach features not only metal-free oxidative C(sp2)–C(sp2) bond formation but also an exclusive 1,2-aryl migration.以易得的N-甲基-N-苯基肉桂酰胺为底物，在路易斯酸存在下与二(三氟乙酸)碘苯（phenyliodine bis(trifluoroacetate), PIFA）发生反应，可通用且高效地构建各类3-芳基喹啉-2-酮类化合物。该新型合成方法不仅实现了无金属氧化C(sp²)-C(sp²)键的形成，还展现出专一的1,2-芳基迁移特性。