Gene expression profiles relevant to alcoholic liver disease mice experimentally infected with V. vulnificus

Patients with liver disease are susceptible to infection with Vibrio vulnificus (V. vulnificus), but the specific reasons remain elusive. Through RNA-seq, we found that when mice with alcoholic liver disease (ALD) were infected with V. vulnificus by gavage, compared with the Pair group, the small intestinal genes affecting intestinal permeability were up-regulated; and the number of differentially expressed genes related to immune functions (e.g., such as cell chemotaxis, leukocyte differentiation, neutrophil degranulation.) decreased in the liver, spleen and blood.

肝病患者易感染创伤弧菌（Vibrio vulnificus, V. vulnificus），但其具体易感原因仍不明晰。本研究借助RNA测序（RNA-seq）发现，当酒精性肝病（ALD）小鼠经灌胃（gavage）感染创伤弧菌后，相较于配对组（Pair group），其小肠内调控肠道通透性的基因表达出现上调；而肝脏、脾脏及血液中，与免疫功能相关的差异表达基因数量有所下降，此类免疫功能涵盖细胞趋化、白细胞分化、中性粒细胞脱颗粒等。