The Role of Myeloid Cells in Parkinson's Disease

The Myeloid cells in Neurodegenerative Diseases (MyND) initiative is a collaborative effort with the goal of creating a multi-omic atlas of myeloid cells from the periphery and from autopsied brains of subjects with Parkinson's disease (PD), Alzheimer's disease (AD), and age-matched controls. We have generated large-scale transcriptomic profiles of CD14+ monocytes from 230 individuals with sporadic PD and age matched healthy subjects. We identified dysregulation of mitochondrial and proteasomal pathways, and single-cell analysis revealed that these pathways are enriched in the intermediate monocytes. We also generated transcriptomic profiles of primary microglia from autopsied brains of 55 PD and control subjects and observed discordant transcriptomic signatures of mitochondrial genes... (for more see dbGaP study page.)

神经退行性疾病髓系细胞研究计划（Myeloid cells in Neurodegenerative Diseases, MyND）是一项合作研究项目，旨在构建帕金森病（Parkinson's disease, PD）、阿尔茨海默病（Alzheimer's disease, AD）患者及年龄匹配对照人群的外周髓系细胞与尸检脑组织髓系细胞的多组学图谱。本项目已对230例散发性帕金森病患者及年龄匹配的健康受试者的CD14+单核细胞（CD14+ monocytes）开展大规模转录组分析，获取其转录组表达谱。研究团队发现线粒体与蛋白酶体通路存在失调现象，单细胞分析显示上述通路在中间型单核细胞中显著富集。本团队还对55例帕金森病患者及对照受试者的尸检脑组织原代小胶质细胞进行了转录组分析，并观察到线粒体基因的转录组特征存在异常差异……（更多详情请参见dbGaP研究页面）