Distinct Brca1 mutations differentially reduce hematopoietic stem cell function
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to survive. They also show that humanization of the mouse Brca1 e with a knocked-in BRCA1 cDNA, but not a mutant BRCA1/5382insC cDNA, fully substitutes for the mouse Brca1 during both embryonic development and hematopoiesis.
提供机构：
UT Southwestern Medical Center
创建时间：
2022-02-20
