Advanced Genomic Techniques in Sequencing of Colorectal Cancer. Advanced Genomic Techniques in Sequencing of Colorectal Cancer

We developed a method that uses allelic imbalance information in combination with phased genomic sequencing to generate mega-haplotypes that can encompass entire chromosome arms. We applied this technique to characterize aneuploidy and chromosomal alterations in colorectal cancers.

本研究开发了一种结合等位基因失衡（allelic imbalance）信息与相位基因组测序（phased genomic sequencing）的方法，可生成能够覆盖整条染色体臂的巨型单倍型（mega-haplotypes）。我们将该技术应用于结直肠癌的染色体非整倍性（aneuploidy）与染色体结构变异特征解析。