JPST000349-10 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-metabolizing enzymes and transporters in order to investigate the potential impact of dysbiosis on drug pharmacokinetics. [Original project description]

肠道菌群失调（Dysbiosis，即肠道菌群组成改变）与包括疾病在内的多种宿主生理状态存在密切关联。本研究旨在通过定量蛋白质组学分析，明确肠道菌群失调对小鼠肝脏与肾脏蛋白质表达水平的影响，并重点关注药物代谢酶与转运体，以探究肠道菌群失调对药物代谢动力学的潜在影响。[原始项目描述]