Visible-Light Induced and Oxygen-Promoted Oxidative Cyclization of Aromatic Enamines for the Synthesis of Quinolines Derivatives

The dual transition metal-visible light photoredox catalysis for the synthesis of quinoline derivatives by using dioxygen as an oxygen source is developed. By using visible light, the direct oxidative cyclization of aromatic enamines with alkynes or alkenes can be achieved at mild conditions with an aid of copper or palladium catalysts, and a variety of multisubstituted quinoline derivatives could be obtained in good to moderate yields under mild reaction conditions.本工作开发了以氧气（dioxygen）为氧源，通过双过渡金属-可见光光氧化还原催化体系合成喹啉衍生物（quinoline derivatives）的方法。在可见光辐照下，辅以铜或钯催化剂，可在温和条件下实现芳香烯胺（aromatic enamines）与炔烃（alkynes）或烯烃（alkenes）的直接氧化环化反应，最终可获得多种多取代喹啉衍生物，收率达中等到良好水平。