Table_1_Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.docx

Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of MDD patients. It has been preliminarily proved that hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 were highly expressed in MDD patients and can be used as diagnostic markers for MDD. Bioinformatics analysis revealed that hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 may affect the neuroplasticity of MDD through the ceRNA mechanism.

环状RNA（circRNAs）在中枢神经系统中呈高表达，已有研究表明其与神经精神疾病存在关联，但目前其在重性抑郁障碍（major depressive disorder, MDD）中的潜在作用仍不明确。本研究证实，重性抑郁障碍患者血液中的环状RNA存在表达紊乱。本研究已初步验证，hsa_circ_0002473、hsa_circ_0079651、hsa_circ_0137187、hsa_circ_0006010及hsa_circ_0113010在重性抑郁障碍患者体内呈高表达，可作为该疾病的诊断标志物。生物信息学分析显示，hsa_circ_0079651、hsa_circ_0137187、hsa_circ_0006010及hsa_circ_0113010可能通过内源竞争RNA（competing endogenous RNA, ceRNA）机制影响重性抑郁障碍的神经可塑性。