Human T-cell dysfunction induced in repeatedly stimulated cultures.
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132727
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资源简介:
We report the changes in mRNA profile of quiescent, activated and dysfunctional human CD8+ T cells in culture according to a protocol of weekly polyclonal stimulations relevant to immunotherapy. mRNA profile of quiescent enriched CD8+ T cells compared to cells after one stimulation with anti-CD3/CD38 beads or 5 to 7 rounds of weekly stimulations.
本研究报道了基于免疫治疗相关的每周多克隆刺激培养方案,体外培养的静息、活化及功能失调的人CD8+ T细胞的mRNA表达谱(mRNA profile)变化。本研究对比了富集静息状态的人CD8+ T细胞,与经抗CD3/抗CD38磁珠(anti-CD3/CD38 beads)单次刺激后的细胞,以及经过5至7轮每周刺激后的细胞的mRNA表达谱。
创建时间:
2021-08-31



