Demographic and matched data of the participants.

Purpose
Oral cancers are the 6th most common malignancy worldwide and oral squamous cell carcinoma, comprises over 90% of oral cancers. This study investigates the relationship between physical activity level during the lifetime and oral squamous cell carcinoma risk.
Methods
100 oral squamous cell carcinoma patients and 200 healthy individuals participated in this case-control study. Physical activity level was evaluated via the Lifetime Physical Activity Questionnaire. The occupational, household, and sports domains of lifetime physical activity were determined. Case and control groups’ participants were matched in terms of sex, age, smoking, and alcohol consumption by the Frequency Matching Method. Mann-Whitney U Test was applied to compare physical activity levels between groups.
Results
The Body Mass Index was higher among cases compared with controls. The average amounts of lifetime physical activity among cases and controls were approximately identical. However, only a statistically significant difference between time spent on total lifetime physical activities and the oral squamous cell carcinoma risk was discovered. Moreover, there were no statistically significant odds ratios in examining the risk associated with each domain of activities.
Conclusions
The total time spent on lifetime physical activity may decrease the risk of oral squamous cell carcinoma; However, the total level and intensity of lifetime physical activity are not significantly associated with the oral squamous cell carcinoma risk. Further studies are required in this field.

研究目的
口腔癌是全球第六大常见恶性肿瘤，其中口腔鳞状细胞癌（oral squamous cell carcinoma）占口腔癌总数的90%以上。本研究旨在探讨终身体力活动水平与口腔鳞状细胞癌发病风险之间的关联。
研究方法
本研究为病例对照研究，共纳入100例口腔鳞状细胞癌患者与200名健康个体。采用终身体力活动问卷（Lifetime Physical Activity Questionnaire）评估受试者的体力活动水平，涵盖职业性、家务性及运动性三类终身体力活动维度。采用频率匹配法（Frequency Matching Method），按照性别、年龄、吸烟及饮酒情况对病例组与对照组受试者进行匹配。采用曼-惠特尼U检验（Mann-Whitney U Test）比较两组间的体力活动水平差异。
研究结果
病例组的体重指数（Body Mass Index）高于对照组。病例组与对照组的终身体力活动平均总量大致相当。但仅在终身总体力活动时长与口腔鳞状细胞癌发病风险之间，观察到具有统计学意义的差异。此外，针对各体力活动维度相关发病风险的分析显示，其比值比（odds ratios）均无统计学显著性。
研究结论
终身总体力活动时长或可降低口腔鳞状细胞癌的发病风险；但终身体力活动的总体水平与强度，与口腔鳞状细胞癌发病风险并无显著关联。该领域仍需开展进一步研究。