MicroRNA Expression Profiling of Hypoxic Cardiomyocytes Treated with Oxygenated Perfluorocarbon Nanobubbles Invitro.

MicroRNAs (miRNAs) are non-coding RNAs responsible for post-transcriptional gene expression regulation through interaction with messenger RNAs (mRNAs). The dataset is the miRNA expression profile of the in-vitro study performed to evaluate oxygenated perfluorocarbon nanobubbles' ability to protect the cardiomyocytes from hypoxia-related cardiomyocytic injury. The results were compared with cardiomyocytes in phosphate-buffered saline (PBS) under normoxia conditions and also after hypoxia (5% O2) treatment. The dataset describes miRNA profiling of cardiomyocytes when treated with and without perfluorocarbon nanobubbles. The data represents the list of miRNA assay and the fold changes. The cardiomyocytes were subjected to severe hypoxia with and without perfluorocarbon nanobubbles for 3.5 hours, and the miRNA expression profiling was performed. This is to mimic acute myocardial infarction milieu, invitro. The miRNA data is especially useful for researchers working on novel biomarkers in acute myocardial infarction or in heart failure/ cardiovascular diseases. The function of the perfluorocarbon nanobubbles could be further enhanced by vascular endothelial growth factor (VEGF) or RGD conjugations. *Global normalization value that is >100 is indicated in yellow in the dataset.

微小核糖核酸（MicroRNAs，miRNAs）是一类非编码RNA，通过与信使核糖核酸（messenger RNAs，mRNAs）相互结合，参与转录后基因表达调控。本数据集源自一项体外研究的miRNA表达谱数据，该研究旨在评估含氧全氟碳纳米气泡（oxygenated perfluorocarbon nanobubbles）对心肌细胞免受缺氧相关性心肌损伤的保护作用。实验将处理组结果与常氧条件下及缺氧（5% O₂）处理后、培养于磷酸缓冲盐溶液（phosphate-buffered saline，PBS）中的心肌细胞进行了对照比较。本数据集收录了施加与未施加全氟碳纳米气泡处理的心肌细胞的miRNA表达谱数据，包含miRNA检测项目列表及其表达倍数变化数据。研究将心肌细胞分为两组，分别在施加与未施加全氟碳纳米气泡的条件下进行3.5小时重度缺氧处理，随后开展miRNA表达谱分析，以此体外模拟急性心肌梗死的病理微环境。该miRNA数据集尤其适用于探索急性心肌梗死、心力衰竭或心血管疾病新型生物标志物的研究人员。全氟碳纳米气泡的保护功能可通过与血管内皮生长因子（vascular endothelial growth factor，VEGF）或RGD肽进行缀合得到进一步增强。*数据集中全局归一化值大于100的条目将以黄色标注。