Demographics PIN.xlsx from Gestational growth trajectories derived from a dynamic fetal–placental scaling law

Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.以往表征子宫内胎儿生长速率的胎儿轨迹研究，主要以拟合优度为依据，而非基于胎儿在子宫内展现的机制特性。本研究采用经过验证的胎儿-胎盘异速生长缩放定律（allometric scaling law），以及胎盘体积增长的第一性原理微分方程模型，生成具备生物学意义的胎儿-胎盘生长曲线。此类生长曲线可为区分健康与高危胎儿生长状态、识别子宫内关键事件的发生时序提供核心研究基础。