Global detection of 915 SARS-CoV-2 genomes encoding a high-risk VYD2311 escape haplotype (F486P+S371F+K444T+N460K+R346T) in 2023 - 2024 surveillance data

VYD2311 HIGH-RISK ESCAPE CONSTELLATION SURVEILLANCE================================================== Target constellation: F486P + S371F + K444T + N460K + R346TReference: Wuhan-Hu-1 (NC_045512.2)Total genomes analysed: 9,356,279Genomes with full 5-mutation constellation: 915 Sample matching sequences: 1. USA/MA-Broad_MGH-16621/2023 2. USA/CO-CDPHE-41673449/2024 3. USA/CA-SEARCH-233211/2024 4. Switzerland/BE-IFIK-231106_os_12/2023 5. USA/CA-CDPH-500130502/2023..915. Interpretation:- This constellation disrupts the VYD2311 epitope at 5 critical residues.VYD2311高逃逸风险突变组合监测 ================================================== 目标突变组合：F486P、S371F、K444T、N460K及R346T 参考序列：Wuhan-Hu-1（NC_045512.2） 总分析基因组数：9,356,279条 携带完整5突变组合的基因组数：915条 匹配序列样本： 1. 美国/马萨诸塞州-Broad_MGH-16621/2023 2. 美国/科罗拉多州-CDPHE-41673449/2024 3. 美国/加利福尼亚州-SEARCH-233211/2024 4. 瑞士/伯尔尼州-IFIK-231106_os_12/2023 5. 美国/加利福尼亚州-CDPH-500130502/2023 ……915. 结果解读：该突变组合会在5个关键残基位点破坏VYD2311抗原表位。