Table1_Measurements of enteral feeding intolerance in critically ill children: a scoping review.docx

ObjectiveTo examine the measurements on enteral feeding intolerance (EFI) in critically ill children.
MethodsThe Joanna Briggs Institute methods for conducting a scoping review were followed. Articles published since 2004 which assessed EFI in critically ill children were identified. A full search strategy was executed in seven English databases (MEDLINE, EMBASE, PubMed, Web of Science, Cochrane Central Register of Controlled Trials, JBI EBP, CINAHL) and four Chinese databases (CNKI, VIP, Wanfang, Sinomed). Two reviewers screened records according to our inclusion and exclusion criteria, and conducted a full-text review of selected articles. The reference lists of all studied selected were screened for additional sources. Relevant data was extracted using a researcher-developed tool.
ResultsOf the 627 articles identified, 32 were included in this scoping review. Most articles focused on the measurement of high gastric residual volume (n = 22), followed by diarrhea (n = 20), and vomiting (n = 9). Most of the studies were of observational-analytic design (13/32) and experimental design (8/32).
ConclusionThis scoping review addressed the complexity and diversity of EFI measurements. Given the importance of adequacy of enteral nutrient intake, we highlighted the necessary to develop individual measurements of EFI, taking the age of children and disease condition into consideration. Further studies can also investigate accurate and objective physiological measurements of EFI to advance EN and improve outcomes in critically ill children.

### 研究目的
探讨重症儿童肠内喂养不耐受（enteral feeding intolerance, EFI）的相关评估指标。

### 研究方法
本研究遵循乔安娜·布里格斯研究所（Joanna Briggs Institute, JBI）的范围综述（scoping review）方法。检索2004年以来发表的、针对重症儿童肠内喂养不耐受的相关文献。通过完整的检索策略覆盖7个英文数据库（MEDLINE、EMBASE、PubMed、Web of Science、Cochrane Central Register of Controlled Trials、JBI EBP、CINAHL）及4个中文数据库（CNKI、VIP、Wanfang、Sinomed）。由2名研究者按照预先设定的纳入与排除标准筛选文献，并对入选文献开展全文审阅；同时筛查所有入选文献的参考文献列表以补充潜在相关来源。采用研究者自制的数据提取工具完成相关数据提取。

### 研究结果
初检出627篇文献，最终纳入32篇文献进行本次范围综述。其中多数研究聚焦于胃残余量升高的评估（n=22），其次为腹泻（n=20）与呕吐（n=9）的评估。纳入研究中，观察性分析类研究设计占比最高（13/32），其次为实验性研究设计（8/32）。

### 研究结论
本范围综述明确了肠内喂养不耐受评估指标的复杂性与多样性。鉴于肠内营养摄入充足性的临床重要性，本研究强调需结合儿童年龄与疾病状态，构建个体化的肠内喂养不耐受评估体系。未来可进一步探索精准且客观的肠内喂养不耐受生理评估指标，以推进肠内营养（enteral nutrition, EN）的应用并改善重症儿童的临床结局。