Additional file 2: of The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Table S1. (a) Summary list of 113 proteins differently expressed in APMAP ko/ko mice, compared to WT mice. (b) List of 2747 proteins identified by LFQ where at least 2 peptides have been detected and a minimum of 2 valid values per group (ko/ko vs wt/wt) was obtained. Displayed with a yellow background are the 105 differently expressed proteins revealed by statistical analysis (t-test: p-value < 0.05). (c) List of 8 differently expressed proteins identified in addition to (b) by imputing missing LFQ values with at least 2 detected peptides and a minimum of 3 valid values for at least one group (ko/ko or wt/wt; t-test: p-value < 0.05), in green left-censored imputated values. (XLSX 540 kb)

补充表S1。(a) APMAP ko/ko小鼠与野生型（Wild Type, WT）小鼠相比，差异表达的113种蛋白质汇总列表。(b) 经无标记定量（Label-Free Quantification, LFQ）鉴定得到的2747种蛋白质列表，此类蛋白质至少被2条肽段检测到，且两组（ko/ko与wt/wt）均至少获得2个有效数值。其中经统计学分析（t检验：p值<0.05）筛选出的105种差异表达蛋白质以黄色背景标注。(c) 除(b)中所列蛋白质外，通过缺失值填补法对至少2条已检测肽段的缺失LFQ值进行填补，且至少一个分组（ko/ko或wt/wt）具备至少3个有效数值，经t检验（p值<0.05）额外鉴定出的8种差异表达蛋白质列表，表格中左侧绿色标注为经左侧删失填补的缺失值。(XLSX 540 kb)