Rattus Genome sequencing and assembly. Rattus

In this study, we aimed to determine the effect of microbiota on NLRP3 inflammasome and the potential mechanism of probiotic antidepressants through chronic unpredictable mild stress (CUMS) rats, as well as fecal transplantation (FMT) experiment.

本研究旨在通过慢性不可预见性温和应激（chronic unpredictable mild stress, CUMS）大鼠模型及粪便移植（fecal transplantation, FMT）实验，明确微生物群（microbiota）对NLRP3炎性小体（NLRP3 inflammasome）的调控作用，并阐明益生菌抗抑郁剂的潜在作用机制。