Studies identified in systematic review.

RCT = randomized controlled trial.w/o = without.HF = heart failure.DM = diabetes mellitus.CV = cardiovascular.NYHA = New York Heart Association.LVH = left ventricular hypertrophy.CVD = cardiovascular disease.BP = blood pressure.HTN = hypertension.SBP = systolic blood pressure.SAE = serious adverse event.DBP = diastolic blood pressure.MI = myocardial infarction.CAD = coronary artery disease.CHD = coronary heart disease.CrCl = creatinine clearance.UK = United Kingdom.ACE = angiotensin converting enzyme.PAD = peripheral arterial disease.CVA = cerebrovascular accident.AF = atrial fibrillation.IHD = ischemic heart disease.ESRD = end = stage renal disease.HD = hemodialysis.CKD = chronic kidney disease.PTCA = percutaneous transluminal coronary angioplasty.TIBI = Total Illness Burden Index.*No inclusion of patients without CKD and therefore no comparison between patients with and without CKD; study assumed established benefit of therapy in the absence of CKD.Studies identified in systematic review.