Gene involved in viral induced Guillain Barre syndrome

Zika virus (ZIKV) causes Guillain-Barre syndrome (GBS) which is a reversible, acute peripheral neuropathy involving varying levels of limb or cranial muscle weaknesses, and diminished deep tendon reflexes. We used a mouse model of ZIKV-induced acute flaccid paralysis with similarities to GBS to identify candidate genes potentially involved in Zika virus-induced paralysis. In two independent studies, RNA extracted from spinal cords (vertebrate column anterior between the hind limbs and posterior the medulla oblongata) of sham-infected, paralyzed, and recovering mice was sequenced on an Illumina NextSeq 500 using the 75 cycle

寨卡病毒（Zika virus, ZIKV）可引发吉兰-巴雷综合征（Guillain-Barre syndrome, GBS），该疾病属于可逆性急性周围神经病，表现为不同程度的肢体或颅肌无力，且伴深部腱反射减弱。本研究构建了与吉兰-巴雷综合征表型相似的寨卡病毒诱导急性弛缓性麻痹小鼠模型，用于筛选潜在参与寨卡病毒致麻痹过程的候选基因。在两项独立研究中，我们对假感染组、麻痹组及恢复组小鼠的脊髓（即脊柱前介于后肢与延髓后方之间的部分）提取的RNA，采用Illumina NextSeq 500测序平台，以75个循环进行测序。