Muscle-specific gene expression changes in normal and high-fat diet in spinal and bulbar muscular atrophy (SBMA). Mus musculus

The pattern of gene expression changes were analyzed in the skeletal muscle of knock-in mouse models of SBMA fed either a normal chow diet (NCD) or a high-fat diet (HFD). Overall design: Microarray analysis was performed in 180-day-old mice (wild type-NCD, wild type-HFD, AR113Q-NCD, and AR113Q-HFD).

本研究对饲喂普通饲料日粮（normal chow diet, NCD）或高脂饮食（high-fat diet, HFD）的脊髓延髓肌萎缩症（Spinal and Bulbar Muscular Atrophy, SBMA）敲入小鼠模型的骨骼肌组织，开展基因表达变化模式分析。
实验设计概述：本实验选取180日龄小鼠，分为四组：野生型-普通饲料组（wild type-NCD）、野生型-高脂饮食组（wild type-HFD）、AR113Q-普通饲料组（AR113Q-NCD）以及AR113Q-高脂饮食组（AR113Q-HFD），并对所有样本进行基因芯片分析。