Remediating the poultry litter resistome

There is significant concern that agricultural use of antimicrobials leads to spill over of antimicrobial resistance (AMR) into the human population. Animal manures contain a large and diverse reservoir of AMR genes. While poultry litter is a rich source of nitrogen that is applied to soil to aid crop growth, it also contains an abundance of AMR genes and mobile genetic elements associated with its dissemination. Reduce this reservoir, and its potential to transmit AMR to pathogens is diminished. Four conditions: intermittent wet-dry, forced aeration, anaerobic, and static incubations were assessed for their impact on the community resistome of poultry litter and bacterial community composition.

学界普遍担忧，农业领域使用抗菌药物会导致抗菌药物耐药性（antimicrobial resistance, AMR）向人类人群传播扩散。动物粪便中蕴藏着种类丰富、数量庞大的抗菌药物耐药性基因库。尽管家禽垫料是一种优质氮源，常被施入土壤以促进作物生长，但其中同时含有大量抗菌药物耐药性基因以及与之相关的可移动遗传元件，易随其施用发生扩散。若能缩减该耐药基因库的规模，其将抗菌药物耐药性传播至病原菌的潜力也会随之降低。本研究评估了四种培养条件——间歇干湿循环、强制曝气、厌氧培养以及静态培养——对家禽垫料菌群耐药组与细菌群落组成的影响。