DNA binding small molecule induces repeat contractions in Huntington's disease

WGS to confirm the absence of mutations induced by cell lines treatments with a DNA binding small molecule, able to induce trinucleotide repeat contractions in Huntington's disease cell lines and in vivo in mouse models.本数据集采用全基因组测序（Whole Genome Sequencing, WGS），旨在验证经DNA结合小分子处理的细胞系未产生该处理诱导的突变；该DNA结合小分子可在亨廷顿病（Huntington's disease）细胞系及小鼠模型体内诱导三核苷酸重复收缩。